Permanent interstitial 125I seed implantation as a salvage therapy for pediatric recurrent or metastatic soft tissue sarcoma after multidisciplinary treatment

World Journal of Surgical Oncology

Research

Yuliang Jiang¹  Lei Lin¹  Lihong Yao¹  Junjie Wang¹  Jinna Li¹  Chen Liu²  Weiqiang Ran³ 

[1] Department of Radiation Oncology, Peking University Third Hospital, Hua-yuan North Road No.49, 100191, Beijing, People’s Republic of China;Department of Radiology, Peking University Third Hospital, 100191, Beijing, People’s Republic of China;Department of Ultrasound, Peking University Third Hospital, 100191, Beijing, People’s Republic of China;

关键词: I seed;    Pediatric;    Soft tissue sarcoma;    Image guided;   

DOI  :  10.1186/s12957-015-0747-7

 received in 2015-07-08, accepted in 2015-12-07,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe management of pediatric recurrent or metastatic soft tissue sarcoma after multimodal treatment remains challenging. We investigated the feasibility, efficacy, and morbidity of permanent interstitial 125I seed implantation under image guidance as a salvage treatment for pediatric patients with recurrent or metastatic soft tissue sarcoma.MethodsThis was a retrospective study of 10 patients who underwent percutaneous ultrasound or computed tomography (CT) guided permanent 125I seed implantation. Postoperative dosimetry was performed for all patients. Actuarial D90 was 121–187.1 Gy (median, 170.3 Gy). The number of 125I seeds implanted was 6–158 (median, 34.5), with a median specific activity of 0.7 mCi per seed (range, 0.62–0.8 mCi); total activity was 4.2–113.76 mCi. Follow-up time was 6–107 months (median, 27.5 months); no patients were lost to follow-up.ResultsThe overall response rate (complete response + partial response) was 8/10 (80 %), including two patients with complete response (CR) (20 %) and five patients with partial response (PR) (60 %). Local control rates after 1 and 2 years were 70.1 and 62.3 %, respectively, with a mean local control time of 70.6 months (95 % confidence interval (CI) 45.1–96.0). Survival rates after 1 and 2 years were 68.6 and 57.1 %, respectively, with a mean survival time of 65.3 months (95 % CI 34.1–96.5). Three patients died from distant metastasis; one died from local recurrence 12 months after seed implantation. Three patients suffered a grade I skin reaction and one developed ulceration. No severe adverse neurologic sequelae or blood vessel damage occurred.ConclusionsImage guided permanent interstitial 125I seed implantation as a salvage treatment appears to have a satisfactory outcome in children with recurrent or metastatic soft tissue sarcoma.

【 授权许可】

CC BY   
© Yao et al. 2015