Postoperative complications affect early recurrence of hepatocellular carcinoma after curative resection

BMC Cancer

Research Article

Bin Li¹  Yan-Ming Zhou²  Cheng-Jun Sui³  Jia-Mei Yang³  Xiao-Feng Zhang³ 

[1] Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China;Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China;Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;

关键词: Hepatocellular carcinoma;    Recurrence;    Resection;    Postoperative complications;   

DOI  :  10.1186/s12885-015-1720-0

 received in 2015-04-28, accepted in 2015-10-08,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPostoperative recurrence remains the major cause of death after curative resection for hepatocellular carcinoma (HCC). This study was conducted to evaluate the impact of postoperative complications on HCC recurrence after curative resection.MethodsThe postoperative outcomes of 274 HCC patients who underwent curative resection were analysed retrospectively.ResultsOf the 247 HCC patients, 103 (37.6 %) patients developed postoperative complications. The occurrence of postoperative complications was found to be associated with a significantly higher tumor recurrence (76.2 % vs. 56.6 %, P = 0.002) and a lower 5-year overall survival rate (27.7 % vs. 42.1 %; P = 0.037) as compared with those without complications. Regarding the recurrence pattern, early recurrence (≤2 years) was more frequently seen in patients with complications than that in patients without complications (54.5 % vs.38.6 %; P = 0.011). Multivariate analysis indicated that postoperative complications occurrence was an independent risk factor for early recurrence (odds ratio [OR] 2.223; 95 % confidence intervals [95 % CI] 1.161–4.258, P = 0.016) and poor overall survival (OR 1.413; 95 % CI, 1.012–1.971, P = 0.042).ConclusionsThe results of the present study indicate that the occurrence of postoperative complications is a predictive factor for HCC recurrence after curative hepatectomy, especially for early recurrence.

【 授权许可】

CC BY   
© Zhou et al. 2015