Crohn’s Anal Fistula: How Bad is It Compared to Ordinary Non-Crohn’s Anal Fistula?

Anal fistula;Crohn’s disease;Recurrence;Risk factor;Adipose tissue-derived stem cells;610

의과대학 의학과 ;

University:서울대학교 대학원

关键词: Anal fistula;    Crohn’s disease;    Recurrence;    Risk factor;    Adipose tissue-derived stem cells;    610;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/132742/1/000000025333.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

non-CD, n= 224, 247 procedures) between August 1998 and December 2012. Data were subjected to a retrospective study through a medical record review. The patients were categorized into CD anal fistula and non-CD anal fistula and further classified into simple fistula and complex fistula.Results: All CD patients were under medical treatment, including infliximab (n= 17). CD anal fistula were more complex type in nature (69.2% vs. 39.2%, P<0.001). The overall wound healing rates were lower (simple type: 90.6 % vs. 100%, complex type: 56.2% vs. 76.2%, P<0.001), the healing time was longer (simple: 129.6 ± 106.7 vs. 51.3 ± 33.9 days, complex type: 152.9 ± 120.3 vs. 102.9 ± 87.5 days, P<0.05), and recurrence rate was higher (simple type: 10.3% vs. 0.0%, complex type 24.3% vs. 6.5%, P<0.001) in CD anal fistula. In complex type CD fistulas, wounds persisted in 32/73 (43.8%) after conventional surgical procedures. Adipose tissue-derived stem cells (ASCs) were applied to 15 of these patients, and complete healing achieved in 11 (73.3 %).Conclusions: Despite combined medical treatment, overall outcomes are still poor after conventional surgical procedures for CD fistula. New treatment strategies, such as ASCs treatment, are needed to improve overall outcome.