Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection

BMC Gastroenterology

卷:21

Ding-Wei Chen¹  Ching-Hui Chuang²  Tsung-Hui Hu³  Pao-Yuan Huang³  Ming-Chao Tsai³  Wei-Ru Cho³  Yu-Chieh Tsai³  Fai-Meng Sou³  Chang-Chun Hsiao⁴  Chee-Chien Yong⁵  Yueh-Wei Liu⁵  Yi-Ju Wu⁵ 

[1] Center for Translational Research in Biomedical Sciences, Liver Transplantation Program and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine;

[2] Department of Nursing, Meiho University;

[3] Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine;

[4] Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital;

[5] Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine;

关键词: ALBI;    NBNC;    Hepatocellular carcinoma;    Resection;    Recurrence;   

DOI  :  10.1186/s12876-021-01944-w

来源: DOAJ

【 摘 要 】

Abstract Background The albumin–bilirubin (ALBI) grade has been validated as a significant prognostic predictor for hepatocellular carcinoma (HCC). However, there is little information about the ALBI grade in patients with non-B non-C HCC (NBNC-HCC) receiving surgery. Aim This study aimed to evaluate the prognostic significance of the ALBI grade in patients with NBNC-HCC after primary curative resection. Method From January 2010 to April 2016, 2137 patients with HCC who received hepatectomy were screened for study eligibility. Finally, a total of 168 NBNC-HCC patients who received primary curative resection were analyzed. The impacts of the ALBI grade on disease-free survival (DFS) and overall survival (OS) were analyzed by multivariate analysis. Results There were 66 (39.3%), 98 (58.3%), and 4 (2.4%) patients with an ALBI grade of I, II, and III, respectively. Patients with an ALBI grade II/III were older (p = 0.002), more likely to have hypoalbuminemia (p < 0.001), and more commonly had Child–Pugh class B (p = 0.009) than patients with an ALBI grade I. After a median follow-up of 76 months, 74 (44%) patients experienced recurrence, and 72 (42.9%) patients died. Multivariate analysis revealed that alpha-fetoprotein (AFP) > 200 ng/mL (p = 0.021), number of tumors (p = 0.001), and tumor stage (p = 0.007) were independent prognostic factors for DFS. Additionally, AFP > 200 ng/mL (p = 0.002), ALBI grade II/III (p = 0.002), and tumor stage (p < 0.001) were independent risk factors for poor OS. Conclusion The preoperative ALBI grade can be used to predict mortality in patients with NBNC-HCC after primary curative resection.

【 授权许可】

Unknown