Antibacterial activities of the methanol extracts and compounds from Erythrina sigmoidea against Gram-negative multi-drug resistant phenotypes

BMC Complementary and Alternative Medicine

Research Article

Doriane E. Djeussi¹  Victor Kuete¹  Jaurès A. K. Noumedem¹  Leonidah K. Omosa²  Bonaventure T. Ngadjui³  Louis P. Sandjo⁴ 

[1] Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;Department of Chemistry, School of Physical Sciences, University of Nairobi, P. O. Box, 30197-00100, Nairobi, Kenya;Department of Organic chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon;Department of Pharmaceutical Sciences, CCS, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil;

关键词: Antibacterial;    Erythrina sigmoidea;    Compounds;    Multidrug resistance;    Neobavaisoflavone;   

DOI  :  10.1186/s12906-015-0978-8

 received in 2015-10-06, accepted in 2015-12-22,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundIn the present study, the methanol extracts from the leaves, as well as compounds namely sigmoidin I (1), atalantoflavone (2), bidwillon A (3), neocyclomorusin (4), 6α-hydroxyphaseollidin (5) and neobavaisoflavone (6) (from the bark extract) were tested for their activities against a panel of Gram-negative bacteria including multi-drug resistant (MDR) phenotypes.MethodsBroth microdilution method was used to determine the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of the extracts as well as compounds 1–6.ResultsThe MIC results indicated that the crude extracts from the leaves and bark of this plant were able to inhibit the growth of 96.3 % of the 27 tested bacteria. Compounds 2–6 displayed selective activities, their inhibitory effects being obtained on 8.3 %, 41.7 %, 58.3 %, 58.3 % and 66.7 % of tested bacteria respectively for 2, 3, 5, 6 and 4. The lowest MIC value of 8 μg/mL was obtained with 6 against Escherichia coli ATCC8739, Enterobacter cloacae ECCI69, Klebsiella pneumoniae KP55, Providencia stuartii NAE16 and Pseudomonas aeruginosa PA01.ConclusionThe present study demonstrates that Erythrina sigmoidea is a potential source of antibacterial drugs to fight against MDR bacteria. Neobavaisoflavone (6) is the main antibacterial consituents of the bark crude extract.

【 授权许可】

CC BY   
© Djeussi et al. 2015