Aconitum lycoctonum L. (Ranunculaceae) mediated biogenic synthesis of silver nanoparticles as potential antioxidant, anti-inflammatory, antimicrobial and antidiabetic agents

BMC Chemistry

Research

Awatif M. E. Omran¹  Suliman Alatawi¹  Mehdi Rahimi²  Muhammad Nauman Khan³  Rasha M. A. Jame⁴  Muhammad Adnan⁵  Alevcan Kaplan⁶  Mohsen Suliman Alatawi⁷  Baber Ali⁸  Sana Wahab⁸  Sarah Abdul Razak⁹  Muhammad Naeem-ul-Hassan^1,10  Nasir Assad^1,10  Zia ur Rehman Khan^1,10  Muhammad Sher^1,10  Muhammad Ammar Javed^1,11 

[1] Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia;Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran;Department of Botany, Islamia College Peshawar, 25120, Peshawar, Pakistan;Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia;Department of Chemistry, Faculty of Education, University of Dalanj, Dalanj, Sudan;Department of Chemistry, Islamia College Peshawar, 25120, Peshawar, Pakistan;Department of Crop and Animal Production, Sason Vocational School, Batman University, 72060, Batman, Turkey;Department of Pediatrics, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia;Department of Plant Sciences, Quaid-I-Azam University, Islamabad, Pakistan;Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia;Institute of Chemistry, University of Sargodha, 40100, Sargodha, Pakistan;Institute of Industrial Biotechnology, Government College University, 54000, Lahore, Pakistan;

关键词: A. lycoctonum;    Antibacterial;    Antidiabetic;    Anti-inflammatory;    Antioxidant;    Silver nanoparticles;   

DOI  :  10.1186/s13065-023-01047-5

 received in 2022-12-03, accepted in 2023-09-22,  发布年份 2023

来源: Springer

【 摘 要 】

In this study, a polar extract of Aconitum lycoctonum L. was used for the synthesis of silver nanoparticles (AgNPs), followed by their characterization using different techniques and evaluation of their potential as antioxidants, amylase inhibitors, anti-inflammatory and antibacterial agents. The formation of AgNPs was detected by a color change, from transparent to dark brown, within 15 min and a surface resonance peak at 460 nm in the UV–visible spectrum. The FTIR spectra confirmed the involvement of various biomolecules in the synthesis of AgNPs. The average diameter of these spherical AgNPs was 67 nm, as shown by the scanning electron micrograph. The inhibition zones showed that the synthesized nanoparticles inhibited the growth of Gram-positive and negative bacteria. FRAP and DPPH assays were used to demonstrate the antioxidant potential of AgNPs. The highest value of FRAP (50.47% AAE/mL) was detected at a concentration of 90 ppm and a DPPH scavenging activity of 69.63% GAE was detected at a concentration of 20 µg/mL of the synthesized AgNPs. 500 µg/mL of the synthesized AgNPs were quite efficient in causing 91.78% denaturation of ovalbumin. The AgNPs mediated by A. lycoctonum also showed an inhibitory effect on α-amylase. Therefore, AgNPs synthesized from A. lycoctonum may serve as potential candidates for antibacterial, antioxidant, anti-inflammatory, and antidiabetic agents.

【 授权许可】

CC BY   
© Springer Nature Switzerland AG 2023

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