Isolation, Identification And Screening Antibacterial Activity from Marine Sponge-Associated Fungi Against Multidrug-Resistant (MDR) Escherichia coli

2nd International Conference on Tropical and Coastal Region Eco Development 2016

地球科学;生态环境科学

Sibero, Mada Triandala^1,2 ; Sabdaningsih, Aninditia^1,2 ; Cristianawati, Olvi^1,2 ; Nuryadi, Handung^2 ; Radjasa, Ocky Karna^3,4 ; Sabdono, Agus^3 ; Trianto, Agus^3

Department of Coastal Resources Management, Diponegoro University, St. Imam Bardjo, SH, No. 15, Semarang

50241, Indonesia^1

Laboratory of Tropical Marine Biotechnology, St. Prof. Soedarto, S.H, Tembalang, Semarang

50241, Indonesia^2

Department of Marine Science, Faculty of Fisheries and Marine Science, Diponegoro University, St. Prof. H. Soedharto, SH, Tembalang, Semarang

50275, Indonesia^3

Ministry of Research, Technology and Higher Education, Indonesia^4

关键词: Anti-bacterial activity;    Antibacterial;    Bloodstream infections;    Gastrointestinal Disease;    Multi-drug resistant;    Multidrug resistants;    Trichoderma;    Urinary tract infections;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/55/1/012028/pdf
DOI  :  10.1088/1755-1315/55/1/012028

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Irrational used of antibiotic in several decades ago causing resistant in bacteria and decreasing the cure rate of infectious diseases. Multidrug-resistant (MDR) Escherichia coli is known to cause various of infectious diseases such as urinary tract infection, nosocomial bloodstream infection, meningitis, bacteraemia, and gastrointestinal disease. Marine sponge-associated fungi have potential as source of new compound to combat MDR E. coli. The aims of this research were to isolate marine sponge-assosiated fungi, to screen potential fungi against MDR E. coli, to identify the potential fungi and its host sponge. There were 29 marine sponge-associated fungi successfully isolated from 9 sponges. Among 29 sponge-associated fungi screened, there were 7 isolates showed antibacterial activity against MDR E. coli. The best inhibition zone produced by MPS 14.1/MT 02 and MPS 14.3/MT 04 from sponge PP.SP.16.14. According to fungi identification result fungus MPS 14.1/MT 02 was identified as Trichoderma asperellum while MPS 14.3/MT 04 was identified as Trichoderma reesei. Sponge identification leaded the PP.SP.16.14 as Cinachyrella sp.