A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China

BMC Gastroenterology

Research Article

Saga Johansson¹  Duowu Zou²  Zhaoshen Li²  John Dent³  Ping Yin⁴  Xiaoping Kang⁵  Xiaoyan Yan⁶  Yanfang Zhao⁶  Xiuqiang Ma⁶  Rui Wang⁶  Jia He⁶  Hong Yan⁷  Qiang Li⁷  Yuantao Hao⁸  Jiqian Fang⁸  Joseph JY Sung⁹  Mari-Ann Wallander^1,10  Wenbin Liu^1,11 

[1] AstraZeneca R&D Mölndal, Sweden;Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China;Department of Gastroenterology, Hepatology & General Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia;Department of Health Statistics, Huazhong Science and Technology University, Wuhan, China;Department of Health Statistics, Peking University, Beijing, China;Department of Health Statistics, Second Military Medical University, Shanghai, China;Department of Health Statistics, Xi'an Jiao Tong University, Xi'an, China;Department of Health Statistics, Zhongshan Medical University, Guangzhou, China;Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China;Department of Public Health and Caring Sciences, Uppsala University, Sweden;Previous Address: AstraZeneca R&D Mölndal, Sweden;Previous Address: R&D Medical Affairs, AstraZeneca Pharmaceutical Company Limited, Shanghai, China;

关键词: Irritable Bowel Syndrome;    Peptic Ulcer Disease;    Gastroesophageal Reflux Disease;    Gastrointestinal Disease;    Reflux Symptom;   

DOI  :  10.1186/1471-230X-10-94

 received in 2010-02-26, accepted in 2010-08-15,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by the Montreal Definition. This study aimed to determine the prevalence of symptom-defined GERD across five regions of China, and to investigate variables associated with GERD.MethodsA representative sample of 18 000 adults (aged 18-80 years) were selected equally from rural and urban areas in each region (n = 1800). According to the Montreal Definition, GERD is present when mild symptoms of heartburn and/or regurgitation occur on ≥2 days a week, or moderate-to-severe symptoms of heartburn and/or regurgitation occur on ≥1 day a week.ResultsIn total, 16 091 participants completed the survey (response rate: 89.4%) and 16 078 responses were suitable for analysis. Applying the Montreal criteria, the prevalence of symptom-defined GERD was 3.1% and varied significantly (p < 0.001) among the five regions (from 1.7% in Guangzhou to 5.1% in Wuhan) and between rural and urban populations (3.8% vs 2.4%). Factors significantly associated with GERD included living in a rural area and a family history of gastrointestinal diseases.ConclusionsThis population-based survey found that the prevalence of symptom-defined GERD in China was 3.1%, which is lower than that found in Western countries.

【 授权许可】

Unknown   
© He et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.