Synthesis and antibacterial activity test of 3-(3-(4-hydroxy-3-methylphenyl)akriloil) coumarin compounds

13th Joint Conference on Chemistry

Ismiyarto^1 ; Rafi'Ah, Fida Hidayatul^1 ; Rizky, Novianita^1 ; Adiwibawa Prasetya, Nor Basid^1 ; Sarjono, Purbowatiningrum Ria^1 ; Gadiwiyana, N.^1

Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia^1

关键词: Anti-bacterial activity;    Antibacterial;    Coumarin compounds;    Disc diffusion methods;    Gram-negative bacteria;    Gram-positive bacterium;    Reimer-Tiemann Reaction;    Staphylococcus aureus;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/509/1/012055/pdf
DOI  :  10.1088/1757-899X/509/1/012055

来源: IOP

【 摘 要 】

A 3-(3-(4-hydroxy-3-methylphenyl)acryloyl) coumarin has been synthesized from 4-hydroxy-3-methylbenzaldehyde with 3-acetylcoumarin. This research includes the synthesis of 4-hydroxy-3-metilbenzaldehid from ortho-cresol through Reimer-Tiemann reaction, synthesis of 3-acetylcoumarin from salicylaldehyde, synthesis of 3-(3-(4-hydroxy-3-methylphenyl)acryloyl)coumarin, and antibacterial activity testing of 3-(3-(4-hydroxy-3-methylphenyl)acryloyl)coumarin compound against Escherichia coli (gram negative bacteria) and Staphylococcus aureus (gram positive bacteria) using the disc diffusion method. The result of Reimer-Tiemann reaction was obtained as a yellow solid of 4-hydroxy-3-methylbenzaldehyde with yield of 31.91%. The synthesis of 3-acetylcoumarin was obtained as a yellow solid with a yield of 95.57%. A 3-(3-(4-hydroxy-3-methylphenyl)acryloyl)coumarin was obtained as a brownish yellow solids with yield of 11.66%. A 3-(3-(4-hydroxy-3-methylphenyl)acryloyl) coumarin has better antibacterial activity than 3-acetylcoumarin compound against Escherichia coli and Staphylococcus aureus.