Bioactive principles in exudate gel from the leaf of Aloe fleurentiniorum, traditionally used as folkloric medicine by local people of Aridah and Fayfa mountains, Saudi Arabia

Arabian Journal of Chemistry

Muhammad H. Sultan¹  Essa Albana²  Hassan Mansour Mogaidi²  Hussein Khobrani²  Ahmed Mutib Sharahily²  Abdulrahman Yahya Faqihi³  Md Shamsher Alam³  Hafiz A. Makeen⁴  Mohamed Eltaib Elmobark⁴  Mohammed Ali Bakkari⁴  Sivakumar Sivagurunathan Moni⁴  Saad S. Alqahtani⁴  Zia ur Rehman⁴  Santhosh Joseph Menachery⁵  Osama A. Madkhali⁶  Saeed Alshahrani⁶  M. Intakhab Alam⁶ 

[1] Corresponding author.;College of Pharmacy, Jazan University, Jazan, Saudi Arabia;Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia;Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan Saudi Arabia;Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia;Pharmacy Practice Research Unit, Clinical Pharmacy Department, College of Pharmacy, Jazan University, Jazan, Saudi Arabia;

关键词: Desert plant;    Aloe fleurentiniorum;    Bioactive constituents;    Anti-bacterial activity;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aloe fleurentiniorum is a desert plant that is occasionally used to treat wounds by local people of Aridah and Fayfa mountains in Saudi Arabia. However, medicinal value of the plant has not been scientifically established. The purpose of this study was to determine the bioactive phytocomponents contained in the exudate gel (EG) from the leaves of Aloe fleurentiniorum using GC–MS and FT-IR studies, as well as antibacterial assays. Medicinally important bioactive compounds were identified using GC–MS analysis. The bioactive compounds are “pregn-5-ene-3α,20-diol”, “16α-methyl-pregnane-11,20-dione”, “3-hydroxy-(3α,5α)-, ursodeoxycholic acid”, “1-heptatriacotanol”, “allopregnane-7α,11α-diol-3,20-dione”, “D-arabino-hexopyranoside”, “2-octadecenoic acid methyl ester”, “D-ribo-hexose,2,6-dideoxy-3-O-methyl glucosamine”, “N-acetyl-N-benzoyl-alpha-D-glucopyranoside”, “nonyl 1-thio pregnenolone”, “5-cholestene-3-ol, 24-methyl-cholestanol”, and “D-allose hexadecanoic acid methyl ester”. Furthermore, specific groups and their respective chemical compounds were identified via FT-IR spectroscopy studies. The FT-IR spectroscopy of EG showed various functional groups at 3354, 2945, 2832, 2523, 2046, 1707, 1451, 1108, 1031, 880, 737 and 610 cm−1. The FT-IR peaks revealed the likely presence of various compounds such as glycosides, flavonoids, steroids, saponins, flavonoids, amino sugars, cutin and isothiocyanate. Moreover, EG produced a wide range of antibacterial effects on some screened human pathogenic bacteria.

【 授权许可】

Unknown