Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges

Materials & Design

Xinghong Ding¹  Chaodong Qian²  Jingjing Lu²  Wen Cheng²  Bingqi Zhu³  Fangmei Zhou³  Zhishan Ding³  Xiaoqing Ye³ 

[1] College of Basic Medical Science, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of China;College of Life Sciences, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of China;College of Medical Technology, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of China;

关键词: Bletilla striata polysaccharide;    Ethanol extract substance;    Hemostasis;    Anti-inflammatory;    Antibacterial;    Wound dressing;   

DOI  :  

来源: DOAJ

【 摘 要 】

Development of a fully functional dressing that can be applied throughout wound healing remains challenging. In this study, Bletilla striata polysaccharide (BSP) and the ethanol extract of B. striata (EEB) were physically blended and vacuum freeze-dried into a new medical dressing with various functions, such as hemostasis, anti-inflammatory, antibacterial and wound healing promotion. The in vivo and in vitro blood coagulation evaluation results showed that the most obvious hemostasis effects coming from the EEB25 sponge was probably due to good water absorption capacity. The drug sensitivity test results showed that the sponges presented a good antibacterial effect originated from the addition of EEB. In addition, the EEB25 sponge showed significant anti-inflammatory effects, as well as excellent biodegradability and biocompatibility. The full-thickness wound experiment illustrated the wound healing rates of EEB25 group on the 8th day and 16th day was 82.76 ± 2.78% and 95.36 ± 3.72%, respectively, which showed significant differences (p < 0.05) in comparison to the model group. Histological observations showed that the EEB25 group formed dense collagen fibers, granulation tissue and numerous new blood vessels on the 16th day, with the skin basically cured. Therefore, BSP/EEB multifunctional composite sponge provided a new perspective for the safe application of wound dressings.

【 授权许可】

Unknown