Effect of concurrent resistance-aerobic training on inflammatory factors and growth hormones in children with type 1 diabetes: a randomized controlled clinical trial

Trials

Research

Ramin Shabani¹  Marzieh Nazari²  Setila Dalili³  Afagh Hassanzadeh-Rad³  Mohammad Ali Esfandiari⁴ 

[1] Department of Exercise Physiology, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran;Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran;Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran;School of Medicine, Guilan University of Medical Sciences, Rasht, Iran;Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: Exercise;    Child;    Diabetes mellitus;    Interleukins;    Insulin-like growth factor I;    Glycated hemoglobin;    Randomized controlled trial;   

DOI  :  10.1186/s13063-023-07553-0

 received in 2023-02-17, accepted in 2023-07-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundExercise training is a major factor in controlling type 1 diabetes mellitus (T1DM) in children. The present study aimed to assess the effect of concurrent resistance-aerobic training on selected inflammatory factors and hormones related to blood glucose homeostasis in children with T1DM.MethodsIn this randomized controlled clinical trial, 40 children (with the mean age of 11.11 ± 2.29 years) were randomly assigned to an experimental (N = 20) or control group (N = 20). They underwent a 16-week training program, composed of concurrent resistance-aerobic training performed intermittently for 60 min three times a week. Before and after training, blood samples were analyzed for glucose homeostasis, selected inflammatory factors, and growth factors. Data were analyzed by paired t-test and analysis of covariance (ANCOVA) in IBM SPSS version 22.ResultsThe exercise training intervention reduced fasting blood sugar index (P = 0.002) and glycosylated hemoglobin significantly (P = 0.003). The growth hormone levels were increased significantly only in the experimental group (P = 0.037), whereas no significant difference was noted in the insulin-like growth factor-1 (P = 0.712). It was also found that interleukin-1β and high-sensitivity C-reactive protein did not change in the experimental or control group as compared to the pretest (P > 0.05).ConclusionAs it was shown, it seems that concurrent resistance-aerobic training may improve blood glucose homeostasis and growth hormone. Therefore, these findings may suggest the benefit from exercise training of moderate intensity in children with T1DM. Besides, we recommend undertaking further clinical trials to determine if the exercise training was effective.Trial registrationThis study was registered in the Iranian Registry of Clinical Trials under the code IRCT20150531022498N30: https://en.irct.ir/trial/41031. Registered on July 26, 2019. All experiments on the participants were following the Declaration of Helsinki.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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