Glycated hemoglobin influence on periodontal status, pathogens and salivary interleukins in type II diabetic Tunisian subjects with chronic periodontitis

Journal of Dental Sciences

Faten Ben Amor¹  Marwa Mrag²  Shadia A. Elsayed³  Soha Fuad Alqadi⁴  Yosra Ayed⁵  Nora Abdelgawad⁶  Asma Kassab⁷ 

[1] Corresponding author. Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt and College of Dentistry, Taibah University, Almadinah Almunawwarah, Saudi Arabia.;Département of Oral and Maxillofacial Surgery, College of Dentistry, Taibah University, Al-Madinah Al-Munawwrah, Saudi Arabia;Hospital, Al-Madinah Al-Munawwrah, Saudi Arabia;Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia;;Department of Oral Basic Science, Taibah University, Dental College &Département of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt;Research Laboratory of Oral Health and Bucco-Facial Rehabilitation, Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia;

关键词: Chronic periodontitis;    Diabetes mellitus;    Glycated hemoglobin;    Pathogens;    Interleukins;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background/purpose: Studies have shown that there is a possible correlation between the amount of glycated hemoglobin and the periodontal status. The goal of this study was to investigate the relationship between glycated hemoglobin (HbA1c) and the prevalence of gingival pathogens and circulating interleukin levels in type II diabetic Tunisian subjects. Material and methods: The research included four groups; 30 healthy subjects (H group), 30 non-diabetic subjects suffering from chronic periodontitis (CP group). Type-II diabetic patients were divided according to HbA1c level into 30 adequately-controlled type-II diabetes subjects (HbA1c ≤ 7 percent (ATIID&CP group)) and 30 inadequately-controlled type-II diabetes subjects and HbA1c > 7 percent (ITIID&CP group). Clinical periodontal condition parameters and assessment of salivary interleukin IL-1beta, IL-6 and IL-10 were assessed. Quantitative Polymerase Chain Reaction used for detection of Subgingival biofilm of periodontal pathogens. Results: Clinical parameters analyzed were positively associated with HbA1c levels (p < 0.05). A. Actinomycetemcomitans were found in 80 percent of ITIID&CP, 65 percent of CP and almost absent in H group. Porphyromonas gingivalis was present in 100 percent of CP, 85 percent of ITIID&CP, 50 percent of ATIID&CP and 3 percent of H group. T. Denticola had an equivalent occurrence. While Tannerella forsythia was scarce in ITIID&CP groups, but abundant in the H group. ITIID&CP had the highest IL-6 and IL-1beta/IL-10 ratios. Conclusion: HBA1c levels affect periodontal status, pathogens and salivary interleukins in Type-II diabetic Tunisians with chronic periodontitis, compared with stable and chronic periodontitis groups and can interact with periodontal infections and increase the inflammatory state.

【 授权许可】

Unknown