High triglyceride levels increase the risk of diabetic microvascular complications: a cross-sectional study

Lipids in Health and Disease

Research

Bin Gao¹  Fei Sun¹  Guohong Zhao¹  Jiahang Li²  Yan Yang²  Lei Shi²  Zhongli Ge²  Zhenxing Nie³ 

[1]Department of Endocrinology, Tangdu Hospital of Air Force Medical University, 710038, Xi’an, China

[2]Department of Pharmacy, Tangdu Hospital of Air Force Medical University, 710038, Xi’an, China

[3]Department of Pharmacy, Tangdu Hospital of Air Force Medical University, 710038, Xi’an, China

[4]Department of Pharmacy, Hanzhong Municipal People’s Hospital, 723000, Hanzhong, China

关键词: Triglyceride;    Diabetes mellitus;    Diabetic nephropathy;    Diabetic neuropathy;    Diabetic retinopathy;   

DOI  :  10.1186/s12944-023-01873-5

 received in 2023-05-13, accepted in 2023-07-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe prevalence of microvascular complications in type 2 diabetes mellitus (T2DM) is increasing. The effect of lipid profiles on diabetic microvascular complications remains debated. This research aimed to study the correlation between lipid profiles and microvascular complications.MethodsThis retrospective cross-sectional study included 1096 T2DM patients. The patients were divided into the control, diabetic retinopathy (DR), nephropathy (DKD), and peripheral neuropathy (DPN) groups based on the existence of corresponding complications. The lipid profiles were analyzed, and the effect on complications was assessed by logistic regression.ResultsCompared with the control group, the diabetic microvascular complications group had a higher dyslipidemia rate. The rate of high TGs increased significantly with an increasing number of complications. High TG levels contributed to the risk of DKD, DR, and DPN [odds ratios (ORs): 2.447, 2.267, 2.252; 95% confidence interval: 1.648–3.633, 1.406–3.655, 1.472–3.445]. In the age (years) > 55, T2DM duration (years) > 10, and HbA1c (%) ≥ 7 groups, the risk of high TGs was higher for DKD (ORs: 2.193, 2.419, 2.082), DR (ORs: 2.069, 2.317, 1.993), and DPN (ORs: 1.811, 1.405, 1.427).ConclusionHigh TG levels increase the risk of diabetic microvascular complications, and patients with older age, longer T2DM duration, and higher HbA1c levels are recommended to keep lipid levels more strictly.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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