Animal models of diabetic microvascular complications: Relevance to clinical features

Biomedicine & Pharmacotherapy

Shah Asma Farooq¹  Zawiślak Grażyna¹  Amany A. Sayed¹  Thakur Gurjeet Singh²  Agnieszka Najda²  Ghadeer M. Albadrani³  Mohamed M. Abdel-Daim³  Ashi Mannan⁴  Randhir Singh⁴ 

[1] Corresponding authors.;Chitkara College of Pharmacy, Chitkara University, Punjab, 140401, India;Laboratory of Quality of Vegetables and Medicinal Plants, Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland;MM College of Pharmacy Maharishi Markandeshwar University, Mullana, Haryana 133207, India;

关键词: Diabetes;    Animal models;    Diabetic retinopathy;    Diabetic neuropathy;    Diabetic nephropathy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Diabetes has become more common in recent years worldwide, and this growth is projected to continue in the future. The primary concern with diabetes is developing various complications, which significantly contribute to the disease's mortality and morbidity. Over time, the condition progresses from the pre-diabetic to the diabetic stage and then to the development of complications. Years and enormous resources are required to evaluate pharmacological interventions to prevent or delay the progression of disease or complications in humans. Appropriate screening models are required to gain a better understanding of both pathogenesis and potential therapeutic agents. Different species of animals are used to evaluate the pharmacological potentials and study the pathogenesis of the disease. Animal models are essential for research because they represent most of the structural, functional, and biochemical characteristics of human diseases. An ideal screening model should mimic the pathogenesis of the disease with identifiable characteristics. A thorough understanding of animal models is required for the experimental design to select an appropriate model. Each animal model has certain advantages and limitations. The present manuscript describes the animal models and their diagnostic characteristics to evaluate microvascular diabetic complications.

【 授权许可】

Unknown