Circulating prekallikrein levels are correlated with lipid levels in the chinese population: a cross-sectional study

Lipids in Health and Disease

Research

Yao Zheng¹  Xijie Wang¹  Xiang Zhao²  Changshun Yang³  Yuanlu Shu⁴  Chengfeng Qiu⁵  Yan Yan⁶ 

[1] College of Biology and Environmental Sciences, Jishou University, 416000, Jishou, P.R. China;Department of General Practice, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Department of Laboratory Medicine, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Evidence-based Medicine and Clinical Center, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Evidence-based Medicine and Clinical Center, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Department of Clinical Pharmacy, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;School of Basic Medical Sciences, University of South China, 421000, Hengyang, P.R. China;School of Public Health and Laboratory Medicine, Hunan University of Medicine, 418000, Huaihua, P.R. China;

关键词: Prekallikrein;    Hypercholesterolemia;    Hypertriglyceridemia;    Lipids;    Cardiovascular diseases;   

DOI  :  10.1186/s12944-023-01849-5

 received in 2023-04-23, accepted in 2023-06-14,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundRecent evidence has revealed that circulating coagulation factor prekallikrein (PK), an important part of the kallikrein-kinin system, regulates cholesterol metabolism, but the association between serum PK and lipid levels is unclear.MethodsThis cross-sectional study included 256 subjects (aged from 1 month to 90 years) who underwent physical examinations at the First People’s Hospital of Huaihua, China. After overnight fasting, serum was collected for PK and lipid testing. Spearman correlation analysis and multivariable logistic regression analysis were used to analyze the association of PK level with lipid levels and the likelihood risk of hyperlipidemia. The possible threshold value of PK was calculated according to the receiver operating characteristic (ROC) curve.ResultsThe median serum PK level was 280.9 µg/mL (IQR 168.0, 377.0), and this level changed with age but not sex. The serum PK level was positively correlated with the serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels. A nonlinear relationship was observed between serum PK and high-density lipoprotein cholesterol (HDL-C) levels. The serum PK level was positively correlated with HDL-C when its level was lower than 240 µg/mL and negatively correlated with HDL-C when its level was higher than 240 µg/mL. The regression analysis demonstrated that an elevated serum PK level was significantly associated with the likelihood risk of hypercholesterolemia and hypertriglyceridemia. The ROC curve showed that the possible threshold values of serum PK for hypercholesterolemia and hypertriglyceridemia occurrences were 344.9 µg/mL and 305.7 µg/mL, respectively.ConclusionsElevated serum PK levels were significantly associated with the likelihood of hypercholesterolemia and hypertriglyceridemia, and the possible threshold values of PK levels were 344.9 µg/mL and 305.70 µg/mL, respectively, suggesting that higher PK levels may be a risk factor for cardiovascular diseases.

【 授权许可】

CC BY   
© The Author(s) 2023

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