Development of a Generator to Power ATP-Driven Molecular Motors

Montemagno, Carlo

Cornell University, Ithaca, NY

关键词: Biosynthesis;    59 Basic Biological Sciences;    Cholesterol;    Atp;    Lipids;   

DOI  :  10.2172/900245
RP-ID  :  DOE/ER/14967-1
RP-ID  :  FG02-99ER14967
RP-ID  :  900245

美国|英语

来源: UNT Digital Library

【 摘 要 】

Here, we report a maximum ATP synthesis rate of 193 nmol/min/mg for thermophilic F{sub 1}F{sub 0}. This rate is somewhat lower than the previously observed maximum rate of 500-700 nmol/min/mg (Pitard et al., 1996). However, ATP synthesis rates vary considerably with experimental conditions, and our observed rates compare favorably with the wide range of rates (40-700 nmol/min/mg) observed by these authors. Future research will focus on maximizing the ATP synthesis rate by adjusting environmental conditions, including the lipid and cholesterol composition of the proteoliposomes.