Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels

SCHIZOPHRENIA RESEARCH

卷:115

Article

Diaz, Francisco J.²  Meary, Alexander^3,4  Arranz, Maria J.⁴  Ruano, Gualberto⁵  Windemuth, Andreas⁵  de Leon, Jose^1,6,7,8,9 

[1] Univ Kentucky, Eastern State Hosp, Mental Hlth Res Ctr, Lexington, KY 40508 USA

[2] Univ Kansas, Sch Med, Dept Biostat, Kansas City, KS USA

[3] INSERM, U841, IMRB, Dept Genet, F-94000 Creteil, France

[4] Kings Coll London, Inst Psychiat, London WC2R 2LS, England

[5] Genomas Inc, Hartford, CT USA

[6] Univ Kentucky, Coll Med, Lexington, KY 40508 USA

[7] Univ Kentucky, Coll Pharm, Lexington, KY 40508 USA

[8] Univ Granada, Dept Psychiat, Granada, Spain

[9] Univ Granada, Inst Neurosci, Granada, Spain

关键词: Antipsychotics;    Olanzapine;    Quetiapine;    Chlorpromazine;    Mirtazapine;    Lipids;    Cholesterol;    Triglycerides;    Hypercholesterolemia;    Hypertriglyceridemia;    Metabolic syndrome;    Acetyl-coenzyme A carboxylase alpha;    Acetyl-coenzyme A carboxylase beta;    Neuropeptide Y;   

DOI  :  10.1016/j.schres.2009.09.038

来源: Elsevier

【 摘 要 】

Acetyl-coenzyme A carboxylase alpha (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associated with hypertriglyceridemia in those taking drugs of interest, but not in controls. Five other ACACA SNPs, three additional NPY SNPs, and seven additional ACACB SNPs Were not significant. (C) 2009 Elsevier B.V. All rights reserved.

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