The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia

BMC Psychiatry

Research Article

Eduard Vieta¹  Anabel Martinez-Aran¹  José Sánchez-Moreno¹  Gabriel Selva-Vera²  Rafael Tabarés-Seisdedos²  José Salazar-Fraile²  Patricia Correa²  Vicent Balanzá-Martínez² 

[1] Ciber en Salud Mental (CIBERSAM). Instituto de Salud Carlos III, Madrid, Spain;the Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain;the Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Blasco-Ibáñez 17, 46010, Valencia, Spain;Ciber en Salud Mental (CIBERSAM). Instituto de Salud Carlos III, Madrid, Spain;

关键词: Olanzapine;    Quetiapine;    Cognitive Enhancement;    Cognitive Improvement;    Conventional Antipsychotic;   

DOI  :  10.1186/1471-244X-10-47

 received in 2009-12-20, accepted in 2010-06-15,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAtypical antipsychotics provide better control of the negative and affective symptoms of schizophrenia when compared with conventional neuroleptics; nevertheless, their heightened ability to improve cognitive dysfunction remains a matter of debate. This study aimed to examine the changes in cognition associated with long-term antipsychotic treatment and to evaluate the effect of the type of antipsychotic (conventional versus novel antipsychotic drugs) on cognitive performance over time.MethodsIn this naturalistic study, we used a comprehensive neuropsychological battery of tests to assess a sample of schizophrenia patients taking either conventional (n = 13) or novel antipsychotics (n = 26) at baseline and at two years after.ResultsContinuous antipsychotic treatment regardless of class was associated with improvement on verbal fluency, executive functions, and visual and verbal memory. Patients taking atypical antipsychotics did not show greater cognitive enhancement over two years than patients taking conventional antipsychotics.ConclusionsAlthough long-term antipsychotic treatment slightly improved cognitive function, the switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of these cognitive deficits.

【 授权许可】

Unknown   
© Selva-Vera et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.