Vitamin D deficiency and dyslipidemia in early pregnancy

BMC Pregnancy and Childbirth

Nasser M. Al-Daghri⁶  Iqbal Z. Turkistani¹  Mona Fouda³  Naemah M. Alshingetti⁴  Eman Sheshah⁵  Amal Al-Serehi²  Naji J. Aljohani⁷  Majed S. Alokail⁶  Soundararajan Krishnaswamy⁶  Abdulrahman Al-Ajlan⁸ 

[1]Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia

[2]Maternal-Fetal Medicine Department, King Fahad Medical City, Riyadh 59406, Saudi Arabia

[3]Department of Medicine, Endocrinology Division, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia

[4]Obstetrics and Gynecology Department, King Salman Bin Abdulaziz Hospital, Riyadh, Saudi Arabia

[5]Diabetes Care Center, King Salman Bin Abdulaziz Hospital, Riyadh, Saudi Arabia

[6]Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia

[7]Specialized Diabetes and Endocrine Center, King Fahad Medical City, Faculty of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11525, Saudi Arabia

[8]Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Kingdom of Saudi Arabia

关键词: Hypertriglyceridemia;    Hypercholesterolemia;    Hypovitaminosis D;    Calcium;    Cholesterol;    Atherogenic;    25(OH)D;   

Others  :  1234505
DOI  :  10.1186/s12884-015-0751-5

 received in 2015-07-07, accepted in 2015-11-21,  发布年份 2015

【 摘 要 】

Background

Vitamin D deficiency is a common nutritional issue and dietary supplementation in the general population, including pregnant women, is generally advised. Appropriately high levels of vitamin D are expected to play a role in containing the glycemic and atherogenic profiles observed in pregnancy. However, the relation between vitamin D status and the lipid metabolic profile in Saudi women, who are known to suffer from chronic vitamin D deficiency and high incidence of obesity and type II DM, during the course of pregnancy is not known.

Methods

In this study, we analyzed the relation between serum vitamin D level and various serum metabolic markers among Saudi women (n = 515) in their first trimester of pregnancy (11.2 ± 3.4 weeks). Coefficients of Pearson correlation and Spearman rank correlation were calculated for Gaussian and non-Gaussian variables, respectively. Serum vitamin D status was defined as (in nmol/L): deficient (<25), insufficient (25–50); sufficient (50–75) and desirable (>75).

Results

Results indicated that vitamin D status was sufficient in only 3.5 % of the study participants and insufficient and deficient in 26.2 % and 68.0 % of participants, respectively. Serum vitamin D values in the overall study population correlated positively with serum levels of total cholesterol (R = 0.172; p < 0.01), triglycerides (R = 0.184; p < 0.01) and corrected calcium (R = 0.141; p < 0.05). In the subgroup of vitamin D deficient subjects (n = 350), log serum vitamin D values correlated with serum triglycerides (R = 0.23; p = 0.002) and cholesterol (R = 0.26; p = 0.001).

Conclusions

The positive correlations between serum vitamin D and the atherogenic factors such as total cholesterol and triglycerides indicate a pro-atherogenic metabolic status in vitamin D deficient expectant mothers. This may represent an adaptation to the high metabolic demands of pregnancy.

【 授权许可】

   
2015 Al-Ajlan et al.

【 图 表 】

Fig. 1.

Fig. 2.

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