The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease

Acta Neuropathologica Communications

Research

Charles DeCarli¹  Robert A. Rissman²  My-Le Nguyen³  Emily Huie³  Brittany N. Dugger³  Rebeca Scalco³  Lee-Way Jin³  Hsin-Pei Wang³  Naomi Saito⁴  Laurel Beckett⁴  Lawrence S. Honig⁵  Delaney A. Flaherty⁶  Andrew F. Teich⁷ 

[1]Alzheimer’s Disease Research Center, Department of Neurology, School of Medicine, University of California Davis, Sacramento, CA, USA

[2]Department of Neurosciences, University of California San Diego, La Jolla, San Diego, CA, USA

[3]Department of Pathology and Laboratory Medicine, School of Medicine, University of California Davis, 4645 2Nd Ave, 3400A Research Building III, 95817, Sacramento, CA, USA

[4]Division of Biostatistics, Department of Public Health Sciences, University of California Davis, Davis, CA, USA

[5]Taub Institute for Research On Alzheimer’s Disease and Aging Brain, Department of Neurology, Columbia University Medical Center, New York, NY, USA

[6]Taub Institute for Research On Alzheimer’s Disease and Aging Brain, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA

[7]Taub Institute for Research On Alzheimer’s Disease and Aging Brain, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA

[8]Taub Institute for Research On Alzheimer’s Disease and Aging Brain, Department of Neurology, Columbia University Medical Center, New York, NY, USA

关键词: Autopsy;    Neurodegeneration;    Tauopathy;    Latino;    LatinX;    Disparities;    Dementia;    Alzheimer disease research centers;    Histology;   

DOI  :  10.1186/s40478-023-01574-1

 received in 2023-03-14, accepted in 2023-04-30,  发布年份 2023

来源: Springer

【 摘 要 】

Despite the increasing demographic diversity of the United States’ aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease (AD). Most autopsy-based studies have focused on cohorts of non-Hispanic White decedents (NHWD), with few studies including Hispanic decedents (HD). We aimed to characterize the neuropathologic landscape of AD in NHWD (n = 185) and HD (n = 92) evaluated in research programs across three institutions: University of California San Diego, University of California Davis, and Columbia University. Only persons with a neuropathologic diagnosis of intermediate/high AD determined by NIA Reagan and/or NIA-AA criteria were included. A frequency-balanced random sample without replacement was drawn from the NHWD group using a 2:1 age and sex matching scheme with HD. Four brain areas were evaluated: posterior hippocampus, frontal, temporal, and parietal cortices. Sections were stained with antibodies against Aβ (4G8) and phosphorylated tau (AT8). We compared the distribution and semi-quantitative densities for neurofibrillary tangles (NFTs), neuropil threads, core, diffuse, and neuritic plaques. All evaluations were conducted by an expert blinded to demographics and group status. Wilcoxon’s two-sample test revealed higher levels of neuritic plaques in the frontal cortex (p = 0.02) and neuropil threads (p = 0.02) in HD, and higher levels of cored plaques in the temporal cortex in NHWD (p = 0.02). Results from ordinal logistic regression controlling for age, sex, and site of origin were similar. In other evaluated brain regions, semi-quantitative scores of plaques, tangles, and threads did not differ statistically between groups. Our results demonstrate HD may be disproportionately burdened by AD-related pathologies in select anatomic regions, particularly tau deposits. Further research is warranted to understand the contributions of demographic, genetic, and environmental factors to heterogeneous pathological presentations.

【 授权许可】

CC BY   
© The Author(s) 2023

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Fig. 7