Therapeutic Effects of Photobiomodulation Therapy on Multiple Sclerosis by Regulating the Inflammatory Process and Controlling Immune Cell Activity: A Novel Promising Treatment Target

Journal of Lasers in Medical Sciences

article

SaeedVafaei-Nezhad¹  SomayehNiknazar³  Ali AsgharPayvandi⁴  AtefehShirazi Tehrani⁵  NavidAhmady Roozbahany⁴  BehnazAhrabi²  Hojjat-allah Abbaszadeh⁶  ShahramDarabi⁷ 

[1] Department of Anatomical Sciences, School of Medicine, Cellular and Molecular Research Center, Birjand University of Medical Sciences;Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences;Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences;Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences;Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences;Assistant professor, Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences;Cellular and Molecular Research Center, Research Institute for Non-Communicable Diseases, Qazvin University of Medical Sciences

关键词: Multiple sclerosis;    Photobiomodulation;    Low-level laser therapy;   

DOI  :  10.34172/jlms.2022.32

学科分类：基础医学

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Introduction: Multiple sclerosis (MS) is one of the autoimmune and chronic diseases of the central ‎nervous system, this disease occurs more frequently in young people and women ‎and leads to neurological symptoms. Oxidative stress, inflammatory process, and ‎oligodendrocyte dysfunction has a pivotal role in the pathophysiology of this ‎disease. Nowadays, it has been reported that Photobiomodulation (PBM) as a non-invasive threat has neuroprotective potential but the exact mechanisms are not understood.   Methods: In this manuscript, we have reviewed the Photobiomodulation effects on MS. in this regard, we used "Photobiomodulation", " Laser therapy", and "Low-level laser therapy" keywords on MS to find related studies on this subject in PubMed, Google scholar, Elsevier, Medline, and Scopus databases.  Results: Photobiomodulation has positive effects on MS by regulating the inflammatory ‎process, controlling immune cell activity, and mitochondrial functions, as well as inhibiting free ‎radicals’ production. ‎ Conclusion: Overall, researchers have suggested that laser therapy could be considered a promising new treatment for neurodegenerative diseases, such as multiple sclerosis.

【 授权许可】

CC BY