The Combined Effect of Photobiomodulation and Curcumin on Acute Skin Wound Healing in Rats

Journal of Lasers in Medical Sciences

article

AbdollahAmini¹  HasanSoleimani¹  FatemehalsadatRezaei²  Seyed KamranGhoreishi³  SufanChien⁴  MohammadBayat⁴ 

[1] Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences;College of Pharmacy, University of Kentucky;Department of Statistics, University of Qom;Price Institute of Surgical Research, University of Louisville and Noveratech LLC of Louisville

关键词: Wound healing;    Curcumin;    Therapies;    Photobiomodulation;    Low-level laser therapy;    Wound closure techniques;   

DOI  :  10.34172/jlms.2021.09

学科分类：基础医学

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Introduction: Abnormal wound repair is a cause for considerable expense, as well as patientmorbidity and mortality. Here, we investigated the combined impact of photobiomodulation (PBM)and curcumin on a rat experimental model of an acute skin wound.Methods: A round full-thickness wound was created on the back of each rat. We divided the rats intothe following four groups. Group one was the control group. Group two received pulse wave (PW)PBM at a dose of 890 nm, 80 Hz, and 0.2 J/cm2. Group 3 received 40 mg/kg curcumin by gastricgavage and group 4 were treated with PWPBM + curcumin. We measured the wound area on days4, 7, and 15, and performed microbiological and tensiometric examinations.Results: There was markedly improved wound contraction in the curcumin (7.5 ± 0.57; P=0.000),PBM (8.5 ± 1.2; P=0.000), and PBM + curcumin (14.5 ± 4.3; P=0.002) groups relative to thecontrol group (25 ± 6). PBM (100 ± 7.3; P=0.005), and PBM + curcumin (98 ± 6; P=0.005) groupsmeaningfully improved tensile strength relative to the control group (61 ± 8.2). On day 15, the PBM(10 ± 5; P=0.000), curcumin (14 ± 4.5, P=0.000), and PBM + curcumin (27.3 ± 8.3; P=0.000)groups meaningfully decreased microbial flora relative to the control group (95 ± 6).Conclusion: We concluded that the PBM and PBM + curcumin groups meaningfully acceleratedwound healing of the acute skin wound in the rats. The results of the PBM group were statisticallymore effective than the curcumin alone and PBM + curcumin-treated groups.

【 授权许可】

CC BY