Demyelination of subcortical nuclei in multiple sclerosis

2nd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

Krutenkova, E.^1 ; Aitmagambetova, G.^1 ; Khodanovich, M.^1 ; Bowen, J.^2,3 ; Gangadharan, B.^3 ; Henson, L.^3 ; Mayadev, A.^3 ; Repovic, P.^3 ; Qian, P.^3 ; Yarnykh, V.^1,2

Neurobiology Lab, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia^1

Vascular Imaging Lab, Department of Radiology, University of Washington, Seattle, United States^2

Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle

WA, United States^3

关键词: Basal ganglia;    Globus pallidus;    Healthy controls;    Multiple sclerosis;    Proton fraction;    Quantitative mris;    Substantia nigra;    Whole brains;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/677/1/012006/pdf
DOI  :  10.1088/1742-6596/677/1/012006

来源: IOP

【 摘 要 】

Myelin containing in basal ganglia in multiple sclerosis patients was evaluated using new noninvasive quantitative MRI method fast whole brain macromolecular proton fraction mapping. Myelin level in globus pallidus and putamen significantly decreased in multiple sclerosis patients as compared with healthy control subjects but not in substantia nigra and caudate nucleus.