Increased serum levels of interleukin-17 and transforming growth factor-β in patients with Graves' disease

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Elvira, D.^1 ; Nasrul, E.^2 ; Sofyan, Y.^3 ; Decroli, E.^4 ; Darwin, E.^5

Allergy-Immunology Division of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia^1

Department of Clinical Pathology, Faculty of Medicine, Andalas University, Padang, Indonesia^2

Department of Anatomy, Faculty of Medicine, Andalas University, Padang, Indonesia^3

Endocrine and Metabolic Division of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia^4

Department of Histology, Faculty of Medicine, Andalas University, Padang, Indonesia^5

关键词: Autoimmune disease;    Clinical diagnostics;    Healthy controls;    Healthy individuals;    Pro-inflammatory cytokines;    Thyroid stimulating hormones;    Transforming growth factor beta;    Transforming growth factors;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012163/pdf
DOI  :  10.1088/1755-1315/125/1/012163

来源: IOP

【 摘 要 】

Graves' disease (GD) is an organ-specific autoimmune disease, characterized by excessive autoantibody levels due to tolerance breakdown of thyroid-specific autoantigens. To determine the role of interleukin-17 (IL-17) and transforming growth factor-ß (TGF-β) in GD, we assessed their serum levels in patients with GD and healthy controls. Thirty patients with hyperthyroidism, goiter, and positive thyroid-stimulating hormone receptor antibody diagnosed as GD, according to the clinical diagnostic criteria for autoimmune thyroid disease. Blood samples were also from 30 healthy individuals matched for age and sex as a control. Serum levels of IL-17 and TGF-ß were by using ELISA. IL-17 and TGF-ß levels (14.43 ± 2.15 pg/mL and 10.44 ± 3.19 pg/mL, respectively) were significantly higher in patients with GD than in controls (7.07 ± 1.45 pg/mL and 4.95 ± 1.35 pg/mL, respectively). However, no correlation between IL-17 and TGF-β level in patients with GD. The elevated serum level of IL-17 and TGF-β in patients with GD reflects Th-2 predominance, which causes increasing of these pro-inflammatory cytokines.