Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach

Biocell

article

EJLAL ABU-EL-RUB¹  RAMADA R. KHASAWNEH¹  FATIMAH A. ALMAHASNEH¹  HANA M. ZEGALLAI³ 

[1] Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University;Physiology and Pathophysiology, Faculty of Medicine, University of Manitoba;Department of Pharmacology & Therapeutics, University of Manitoba;DREAM, Children’s Hospital Research Institute of Manitoba

关键词: Mesencyhmal stem cells;    Secretome;    Immuno-modulation;    Cytokines;    Growth factors;   

DOI  :  10.32604/biocell.2022.018306

学科分类：仪器

来源: Biocell

【 摘 要 】

The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells (MSCs), generally referred to as the MSCs derived secretome, has substantial potential for the treatment of many chronic and degenerative diseases. MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases. Herein, we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings.

【 授权许可】

CC BY