Role of vasoactive intestinal peptide in osteoarthritis

Journal of Biomedical Science

Review

Hua Wang¹  Wei Jiang¹  Wei Luo²  Yu-sheng Li² 

[1] Department of Bone and Joint, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, 518020, Shenzhen, Guangdong, China;Department of Orthopaedics, Xiang-ya Hospital, Central South University, 410078, Changsha, Hunan, China;

关键词: Vasoactive intestinal peptide;    Osteoarthritis;    Cytokines;    VIP receptors;    Immuno-modulation;   

DOI  :  10.1186/s12929-016-0280-1

 received in 2016-04-18, accepted in 2016-08-09,  发布年份 2016

来源: Springer

【 摘 要 】

Vasoactive intestinal peptide (VIP) plays important roles in many biological functions, such as, stimulation of contractility in the heart, vasodilation, promoting neuroendocrine-immune communication, lowering arterial blood pressure, and anti-inflammatory and immune-modulatory activity. Osteoarthritis (OA) is a chronic and degenerative bone disease, which is one of the most common causes of disability and most common in both sexes as people become older. Interestingly VIP can prevent chronic cartilage damage and joint remodeling. This review article provides update information on the association of VIP and OA and its treatment. Evidences suggest that VIP is down-regulated in synovial fluid of OA, and VIP down-regulation leads to increase in the production of pro-inflammatory cytokines that might contribute to the pathogenesis of OA; however contradictory reports also exist suggesting that accumulation of VIP in joints can also contribute OA. A number of studies indicated that up-regulation of VIP can counteract the action of pro-inflammatory stimuli and alleviate the pain in OA. More clinical investigations are necessary to determine the biology of VIP and its therapeutic potential in OA that might represent the future standards of care for OA.

【 授权许可】

CC BY   
© The Author(s). 2016