Shining the light on mesenchymal stem cell-derived exosomes in breast cancer

Stem Cell Research & Therapy

Review

Moaed E. Al-Gazally¹  Fahad Alsaikhan²  Ali Thaeer Hammid³  Ria Margiana⁴  Ghulam Yasin⁵  Irfan Ahmad⁶  Homayoon Siahmansouri⁷  Ghaidaa Raheem Lateef Al-Awsi⁸  Indrajit Patra⁹  Iroda Rasulova^1,10  Mazin A. A. Najm^1,11  Hamzah H. Kzar^1,12 

[1] College of Medicine, University of Al-Ameed, Karbala, Iraq;College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia;Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja’afar Al-Sadiq University, Baghdad, Iraq;Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia;Dr. Soetomo General Academic Hospital, Surabaya, Indonesia;Department of Botany, Bahauddin Zakariya University, Multan, Pakistan;Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia;Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Radiological Techniques, Al-Mustaqbal University College, Babylon, Iraq;Independent Researcher, Durgapur, West Bengal, India;Independent Researcher, “Kasmed” Private Medical Centre, Tashkent, Uzbekistan;Pharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq;Veterinary Medicine College, Al-Qasim Green University, Al-Qasim, Iraq;

关键词: Extracellular vesicles;    Tumor;    Exosome;    Breast cancer;    Mesenchymal stem cell;   

DOI  :  10.1186/s13287-023-03245-3

 received in 2022-04-26, accepted in 2023-01-18,  发布年份 2023

来源: Springer

【 摘 要 】

In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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