Single-Chain Fv-Streptavidin Substantially Improved Therapeutic Index in Multistep Targeting Directed at Disialoganglioside GD2.

Cheung, N. K. V. ; Modak, S. ; Lin, Y. ; Guo, H. ; Zanzonico, P.

Technical Information Center Oak Ridge Tennessee

关键词: Gangliosides;    Tumor;    Toxicity;    Neuroblastoma;    Cells(Biology);   

RP-ID  :  DE2004828873

学科分类：工程和技术（综合）

美国|英语

来源: National Technical Reports Library

【 摘 要 】

Multistep targeting can improve the therapeutic index of antibody- based targeting, particularly relevant to pediatric tumors where acute toxicity and late effects of treatment are major concerns. Neuroblastoma is uniquely suited for such investigations because of its abundance of surface ganglioside GD2.