Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing

Stem Cell Research & Therapy

Review

Phil Stephens¹  Frank A. D. T. G. Wagener²  E. M. Ongkosuwito²  Johannes W. Von den Hoff²  Zhihao Wang²  Rob Knight³ 

[1] Advanced Therapeutics Group, School of Dentistry, Cardiff University, Cardiff, Wales, UK;Department of Dentistry, Orthodontics and Craniofacial Biology, Research Institute for Medical Innovation, Radboud University Medical Centre, 6525EX, Nijmegen, The Netherlands;Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, USA;

关键词: Stem cells;    Extracellular vesicles;    Exosome;    Orofacial soft tissues;    Scar;    Fibrosis;   

DOI  :  10.1186/s13287-023-03423-3

 received in 2022-10-10, accepted in 2023-07-20,  发布年份 2023

来源: Springer

【 摘 要 】

Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper skin, mucosa and muscle regeneration during wound repair. This may hamper maxillofacial growth and speech development. To promote the regeneration of injured orofacial soft tissue and attenuate scarring and fibrosis, intraoral and extraoral stem cells have been studied for their properties of facilitating maintenance and repair processes. In addition, the administration of stem cell-derived extracellular vesicles (EVs) may prevent fibrosis and promote the regeneration of orofacial soft tissues. Applying stem cells and EVs to treat orofacial defects forms a challenging but promising strategy to optimize treatment. This review provides an overview of the putative pitfalls, promises and the future of stem cells and EV therapy, focused on orofacial soft tissue regeneration.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023