Strategies for the Development of Cell Lines for Ex Vivo Gene Therapy in the Central Nervous System

Cell Transplantation

Review

Claudia G. Castillo¹  Jana Mejía-Toiber²  Magda Giordano² 

[1] Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;Laboratorio de Plasticidad Neuronal, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de Mexico, Querétaro, Mexico;

关键词: Central nervous system disorders;    Cell lines;    Ex vivo gene therapy;    Development strategies;   

DOI  :  10.3727/096368910X546599

 received in 2010-03-19, accepted in 2010-11-25,  发布年份 2011

来源: Sage Journals

【 摘 要 】

Disorders of the central nervous system (CNS) as a result of trauma or ischemic or neurodegenerative processes still pose a challenge for modern medicine. Due to the complexity of the CNS, and in spite of the advances in the knowledge of its anatomy, pharmacology, and molecular and cellular biology, treatments for these diseases are still limited. The development of cell lines as a source for transplantation into the damaged CNS (cell therapy), and more recently their genetic modification to favor the expression and delivery of molecules with therapeutic potential (ex vivo gene therapy), are some of the techniques used in search of novel restorative strategies. This article reviews the different approaches that have been used and perfected during the last decade to generate cell lines and their use in experimental models of neuronal damage, and evaluates the prospects of applying these methods to treat CNS disorders.

【 授权许可】

Unknown   
© 2011 Cognizant Comm. Corp.