期刊论文详细信息
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 卷:63
The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders
Review
Costales, Jesse1  Kolevzon, Alexander1,2,3,4,5 
[1] Dept Psychiat, New York, NY USA
[2] Dept Pediat, St Louis, MO USA
[3] Seaver Autism Ctr Res & Treatment, New York, NY USA
[4] Friedman Brain Inst, New York, NY USA
[5] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
关键词: IGF-1;    Insulin-like growth factor 1;    Neurotrophic factors;    Central nervous system disorders;    CNS development;    Neurodevelopmental disorders;    ASD;    Autism spectrum disorder;    Fragile X syndrome;    Phelan-McDermid syndrome;    Rett syndrome;   
DOI  :  10.1016/j.neubiorev.2016.01.001
来源: Elsevier
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【 摘 要 】

Central nervous system (CNS) development is a finely tuned process that relies on multiple factors and intricate pathways to ensure proper neuronal differentiation, maturation, and connectivity. Disruption of this process can cause significant impairments in CNS functioning and lead to debilitating disorders that impact motor and language skills, behavior, and cognitive functioning. Recent studies focused on understanding the underlying cellular mechanisms of neurodevelopmental disorders have identified a crucial role for insulin-like growth factor-1 (IGF-1) in normal CNS development. Work in model systems has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 is administered, and several clinical studies have shown promise of efficacy in disorders of the CNS, including autism spectrum disorder (ASD). In this review, we explore the molecular pathways and downstream effects of IGF-1 and summarize the results of completed and ongoing pre-clinical and clinical trials using IGF-1 as a pharmacologic intervention in various CNS disorders. This aim of this review is to provide evidence for the potential of IGF-1 as a treatment for neurodevelopmental disorders and ASD. (C) 2016 Elsevier Ltd. All rights reserved.

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