Gold nanoparticles and their coatings, their effect on cells and their interaction with radiation

30th International Conference on Photonic, Electronic, and Atomic Collisions

Grellet, Sophie^1 ; mialek, Malgorzata A.^2,3 ; Mason, Nigel J.^3 ; Golding, Jon^1

School of Life, Health and Chemical Sciences, Open University, Milton Keynes

MK7 6AA, United Kingdom^1

Dept. of Control and Energy Engineering, Gdansk University of Technology Gabriela, Narutowicza 11/12, Gdansk

80-233, Poland^2

School of Physical Sciences, Open University, Milton Keynes

MK7 6AA, United Kingdom^3

关键词: Breast tissues;    Cell lines;    In-vitro;    Low costs;    Nanometres;    Sugar moiety;    Synthesised;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/875/5/042013/pdf
DOI  :  10.1088/1742-6596/875/5/042013

来源: IOP

【 摘 要 】

Synopsis Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or polyethylene glycolamine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. In addition to the observed intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics.