Limit of Detection in X-ray Diffraction Measurements of Tissue Equivalent Samples

International Conference on Bio-Medical Instrumentation and related Engineering and Physical Sciences

物理学;医药卫生

Zheng, Y.^1 ; Vassiljev, N.^1 ; Konstantinidis, A.^2 ; Griffiths, J.^1,3 ; Speller, R.^1

Department of Medical Physics and Biomedical Engineering, University College London, London

WC1E 6BT, United Kingdom^1

Diagnostic Radiology and Radiation Protection, Christie Medical Physics and Engineering, Christie NHS Foundation Trust, Manchester

M20 4BX, United Kingdom^2

Institute of Biomedical Engineering, University College London, London

WC1E 6BT, United Kingdom^3

关键词: Breast tissues;    Breast tumour;    Diffraction peaks;    Extent of disease;    Limit of detection;    Minimum detectable limits;    New approaches;    X-ray diffraction measurements;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/637/1/012037/pdf
DOI  :  10.1088/1742-6596/637/1/012037

学科分类：卫生学

来源: IOP

【 摘 要 】

There is a suggestion of a new approach to mammography whereby following a conventional mammogram, the radiologist could interrogate suspicious regions using X-ray diffraction whilst the patient is still present and to establish the true extent of disease. A starting point for this work is to quantify the minimum detectable amount of breast cancer within a realistic thickness phantom. Perspex has a similar diffraction pattern to healthy breast tissue whilst water is similar to breast tumour, hence these two materials are used as tissue equivalent test objects for X-ray diffraction measurements. The preliminary results show linear agreement between the ratio of Perspex to water and the ratio of the diffraction peak intensities at 0.7 nm-1and 1.5 nm-1. The minimum detectable limit for a component of the two 'tissue' mix was found to be 4.1%. This suggests that X-ray diffraction can be used to quantify tissue like mixtures down to the 4.1% / 95.9% mix level and hence has a strong potential for delineating the extent of infiltration disease.