Emerging Patterns in the Distribution of Trace Elements in Ovarian, Invasive and In-Situ Breast Cancer

22nd International Congress on X-Ray Optics and Microanalysis

Al-Ebraheem, A.^1 ; Dao, E.^1 ; Geraki, K.^2 ; Farquharson, M.J.^1

Department of Medical Physics and Applied Radiation Sciences, McMaster University, 1280Main St, W Hamilton, ON, L8S 4K1, Canada^1

Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxon, OX11 0DE, United Kingdom^2

关键词: Breast tissues;    Cellular distributions;    Ductal carcinoma in situ;    Emerging patterns;    Invasive ductal carcinomata;    Ovarian cancers;    Surrounding regions;    Synchrotron radiation X-ray fluorescence;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/499/1/012014/pdf
DOI  :  10.1088/1742-6596/499/1/012014

来源: IOP

【 摘 要 】

Breast cancer is the most common cancer and ovarian cancer is the 8th most common cancer affecting women worldwide. This study highlights the changes of trace element levels accompanied by the progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) of the breast, using micro probe Synchrotron Radiation X-ray Fluorescence (μSRXRF). The average values for the increase in Ca, Fe and Zn in tumour regions with respect to surrounding regions for the DCIS samples were significantly higher compared to the increase in the IDC samples (P