Fucoidan cytotoxicity against human breast cancer T47D cell line increases with higher level of sulfate ester group

International Conference on Chemistry and Material Science 2017

化学;材料科学

Saepudin, Endang^1 ; Qosthalani, Fildzah Alfita^1 ; Sinurat, Ellya^2

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Indonesia^1

Research and Development Center of Marine and Fisheries Product Processing and Biotechnology, Jalan KS. Tubun Petamburan VI, Slipi, Central Jakarta

10260, Indonesia^2

关键词: Anticancer activities;    Cell lines;    Cytotoxic activities;    Fucoidans;    Human breast cancer;    Sulfate content;    Sulfate esters;    Sulfate levels;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/299/1/012025/pdf
DOI  :  10.1088/1757-899X/299/1/012025

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

The anticancer activity of different sulfate ester group content in different molecular weight was examined. The anticancer activity was achieved in vitro on human breast cancer T47D cell line. Fucoidan with lower molecular weight (5.79 kDa) tends to have lower sulfate ester group content (8.69%) and resulted in higher IC50value (184.22 μg/mL). While fucoidan with higher molecular weight (785.12 kDa) tends to have higher sulfate level (18.63%) and achieved lower IC50value (75.69 μg/mL). The result showed that in order to maintain fucoidan cytotoxic activity against human breast cancer T47D cell line, the sulfate content should be remain high. Keywords: fucoidan, sulfate ester group, human breast cancer.