Sustained Running in Rats Administered Corticosterone Prevents the Development of Depressive Behaviors and Enhances Hippocampal Neurogenesis and Synaptic Plasticity without Increasing Neurotrophic Factor Levels

Cell Transplantation

Article

En-Dong Zhang¹  Tatia M. C. Lee²  Ang Li³  Suk-Yu Yau⁴  Kwok-Fai So⁵  Brian R. Christie⁶  Aimin Xu⁷ 

[1] Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong;Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong;State Key Laboratory of Brain and Cognitive Science, The University of Hong Kong, Pokfulam, Hong Kong;Cognitive Affective Neuroscience, The University of Hong Kong, Pokfulam, Hong Kong;Laboratory of Neuropsychology, The University of Hong Kong, Pokfulam, Hong Kong;Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong;State Key Laboratory of Brain and Cognitive Science, The University of Hong Kong, Pokfulam, Hong Kong;Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR;Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong;State Key Laboratory of Brain and Cognitive Science, The University of Hong Kong, Pokfulam, Hong Kong;Research Centre of Heart, Brain, Hormone and Healthy Ageing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong;Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong;State Key Laboratory of Brain and Cognitive Science, The University of Hong Kong, Pokfulam, Hong Kong;Research Centre of Heart, Brain, Hormone and Healthy Ageing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong;Department of Ophthalmology, The University of Hong Kong, Pokfulam, Hong Kong;GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China;Division of Medical Sciences, The University of Victoria, Victoria, British Columbia, Canada;Research Centre of Heart, Brain, Hormone and Healthy Ageing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong;Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR;Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong;State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong;

关键词: Hippocampal neurogenesis;    Depression-like behavior;    Synaptic plasticity;    Physical exercise;    Brain-derived neurotrophic factor;    Insulin-like growth factor;   

DOI  :  10.3727/096368914X678490

 received in 2013-11-06, accepted in 2014-01-28,  发布年份 2014

来源: Sage Journals

【 摘 要 】

We have previously shown that voluntary running acts as an anxiolytic and ameliorates deficits in hippocampal neurogenesis and spatial learning. It also reduces depression-like behaviors that are normally observed in rats that were administered either low (30 mg/kg) or moderate (40 mg/kg) doses of corticosterone (CORT). However, the protective effects of running were absent in rats treated with a high (50 mg/kg) dose of CORT. We examined whether allowing animals to exercise for 2 weeks prior and/or concurrently with the administration of 50 mg/kg CORT treatment could have similar protective effects. We examined hippocampal neurogenesis using immuno-histochemical staining of proliferative and survival cells with the thymidine analogs (BrdU, CIdU, and IdU). In addition, we monitored synaptic protein expression and quantified the levels of neurotrophic factors in these animals as well as performing behavioral analyses (forced swim test and sucrose preference test). Our results indicate that the depressive phenotype and reductions in neurogenesis that normally accompany high CORT administration could only be prevented by allowing animals to exercise both prior to and concurrently with the CORT administration period. These animals also showed increases in both synaptophysin and PSD-95 protein levels, but surprisingly, neither brain-derived neurotrophic factor (BDNF) nor insulin-like growth factor 1 (IGF-1) levels were increased in these animals. The results suggest that persistent exercise can strengthen resilience to stress by promoting hippocampal neurogenesis and increasing synaptic protein levels, thereby reducing the deleterious effects of stress.

【 授权许可】

Unknown   
© 2014 Cognizant Comm. Corp.

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