Exploring the link between inflammation and mental disorders

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Effendy, E.^1

Lect. of Psychiatry Department, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia^1

关键词: C-reactive proteins;    Clinical symptoms;    Hippocampal neurogenesis;    Major depressive disorder (MDD);    Mental disorders;    Pro-inflammatory cytokines;    Serum concentration;    Systemic inflammation;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012187/pdf
DOI  :  10.1088/1755-1315/125/1/012187

来源: IOP

【 摘 要 】

Mental disorders constitute 13% of the global disease burden. Schizophrenia, major depressive disorders (MDD) and bipolar disorders are among the most disabling disorders. Some of the inflammatory markers such as homocysteine, tumor necrosis alpha (TNF), C-reactive protein (CRP), and interleukin (IL)-6 have a contribution to influence mental disorder. The serum concentration of C-reactive protein (CRP) wasusedas a nonspecific index of systemic inflammation. Elevated levels of CRP as evidence for an inflammatory etiology of schizophrenia, and as indicators of more severe clinical symptoms and psychopathology of schizophrenia. The inflammatory marker also increases in the depressed patient. Proinflammatory cytokines might inhibit hippocampal neurogenesis which could lead to a reduced hippocampal volume, which is in depression. Anxiety symptoms were correlated to increase cytokine levels. Elevated inflammation in particular found in both men and women with the onset of anxiety disorder later in life.