Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress

BMC Complementary Medicine and Therapies

Dae Youn Hwang¹  Jeffrey J. Moffat²  Soonil Kim³  Joung-Wook Seo⁴  Tae-Wan Kim⁴  Ri-Na Lim⁴  Minhan Ka⁴  Young-Ju Lee⁴  Hye Ryeong Kim⁵ 

[1] Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, 50463, Miryang, Republic of Korea;Department of Neurology, University of California, San Francisco, 94143, San Francisco, CA, USA;Olmanfood Co., Ltd, 03709, Seoul, Republic of Korea;Pharmacology and Drug Abuse Research Group, Research Center for Convergence Toxicology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea;Pharmacology and Drug Abuse Research Group, Research Center for Convergence Toxicology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea;Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, 50463, Miryang, Republic of Korea;Laboratory Animal Center, Korea Brain Research Institute, 61062, Daegu, Republic of Korea;

关键词: Menopausal depression;    Ovariectomized rats;    Asparagus cochinchinensis;    Chronic mild stress;    Inflammatory cytokines;    Corticosterone;    Depression-like behavior;    BDNF-TrkB signaling;   

DOI  :  10.1186/s12906-020-03121-0

来源: Springer

【 摘 要 】

BackgroundDepression is a serious and common psychiatric disorder generally affecting more women than men. A woman’s risk of developing depression increases steadily with age, and higher incidence is associated with the onset of menopause. Here we evaluated the antidepressant properties of Asparagus cochinchinensis (AC) extract and investigated its underlying mechanisms in a rat menopausal depression model.MethodsTo model this menopausal depression, we induced a menopause-like state in rats via ovariectomy and exposed them to chronic unpredictable mild stress (CUMS) for 6 weeks, which promotes the development of depression-like symptoms. During the final 4 weeks of CUMS, rats were treated with either AC extract (1000 or 2000 mg/kg, PO), which has been reported to provide antidepressant effects, or with the tricyclic antidepressant imipramine (10 mg/kg, IP).ResultsWe report that CUMS promotes depression-like behavior and significantly increases serum corticosterone and inflammatory cytokine levels in the serum of ovariectomized (OVX) rats. We also found that CUMS decreases the expression of brain-derived neurotrophic factor (BDNF) and its primary receptor, tropomyosin receptor kinase B (TrkB), in OVX rats, and treatment with AC extract rescues both BDNF and TrkB expression levels.ConclusionThese results suggest that AC extract exerts antidepressant effects, possibly via modulation of the BDNF-TrkB pathway, in a rat model of menopausal depression.

【 授权许可】

CC BY