The effects of Cosmos caudatus (ulam raja) on dynamic and cellular bone histomorphometry in ovariectomized rats

BMC Research Notes

Norliza Muhammad²  Elvy Suhana Mohd Ramli³  Zulaikha Sahhugi¹  Norazlina Mohamed² 

[1] Department of Biomedical Sciences, Faculty of Health Sciences, Kuala Lumpur, Malaysia;Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Center, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia;Department of Anatomy, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia

关键词: Ovariectomized rats;    Bone histomorphometry;    Femur;    Osteoporosis;    Cosmos caudatus;   

Others  :  1142383
DOI  :  10.1186/1756-0500-6-239

 received in 2013-02-07, accepted in 2013-06-21,  发布年份 2013

【 摘 要 】

Background

Cosmos caudatus is a local plant which has antioxidant properties and contains high calcium. It is also reported to be able to strengthen the bone. This report is an extension to previously published article in Evidence Based Complementary and Alternative Medicine (doi:10.1155/2012/817814). In this study, we determined the effectiveness of C. caudatus as an alternative treatment for osteoporosis due to post-menopause by looking at the dynamic and cellular paramaters of bone histomorphometry.

Methods

Forty female Wistar rats were divided into four groups i.e. sham operated, ovariectomized, ovariectomized treated with calcium 1% ad libitum and ovariectomized force-fed with 500 mg/kg C. caudatus extract. Treatment was given six days a week for eight weeks.

Results

Dynamic and cellular histomorphometry parameters were measured. C. caudatus increased double-labeled surface (dLS/BS), mineral appositional rate (MAR), osteoid volume (OV/BV) and osteoblast surface (Ob.S/BS). C. caudatus also gave better results compared to calcium 1% in the osteoid volume (OV/BV) parameter.

Conclusions

C. caudatus at the 500 mg/kg dose may be an alternative treatment in restoring bone damage that may occur in post-menopausal women.

【 授权许可】

   
2013 Mohamed et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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