Adult Hippocampal Neurogenesis: A Possible Way how Physical Exercise Counteracts Stress

Cell Transplantation

Article

Benson Wui-Man Lau¹  Suk-Yu Yau¹  Kwok-Fai So² 

[1] Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China;The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China;Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China;Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China;The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China;Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China;Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China;

关键词: Hippocampal neurogenesis;    Physical exercise;    Stress;    Dendritic plasticity;   

DOI  :  10.3727/096368910X532846

来源: Sage Journals

【 摘 要 】

It was considered that neurogenesis only occurred during the embryonic and developmental stage. This view has greatly changed since the discovery of adult neurogenesis in two brain regions: the hippocampus and the olfactory bulb. Recently, it is suggested that altered hippocampal neurogenesis is related to pathophysiology of mood disorders and mechanism of antidepressant treatments. Accumulating knowledge about the effects of physical exercise on brain function suggests a special role of adult hippocampal neurogenesis in cognitive and mental health, even though the functional significance of adult neurogenesis is still debated. The beneficial effects of running correlating with increased adult neurogenesis may provide a hint that newborn neurons may be involved, at least in part, in the counteractive mechanism of physical exercise on stress-related disorders, like depression. The present review provides an overview of recent findings to emphasize the possible involvement of hippocampal neurogenesis in mediating the beneficial effects of physical exercise on counteracting stress.

【 授权许可】

Unknown   
© 2011 Cognizant Comm. Corp.