Is osteoporosis an autoimmune mediated disorder?

Bone Reports

Linda Agnew¹  Rosebella A. Iseme²  Brian Kelly³  Mark Mcevoy³  John Attia³  Frederick R. Walker³ 

[1] Brain Behaviour Research Group, School of Science and Technology, University of New England, Armidale, NSW 2351, Australia;Department of Population and Reproductive Health, School of Public Health, Kenyatta University, P.O. Box 43844 –, 00100, Nairobi, Kenya;School of Medicine & Public Health, The University of Newcastle, Callaghan, NSW, 2308, Australia;

关键词: Osteoporosis;    Autoantibodies;    Bone remodelling;    Bone mineral density;    Fractures;   

DOI  :  10.1016/j.bonr.2017.10.003

来源: DOAJ

【 摘 要 】

The last two decades have marked a growing understanding of the interaction occurring between bone and immune cells. The chronic inflammation and immune system dysfunction commonly observed to occur during the ageing process and as part of a range of other pathological conditions, commonly associated with osteoporosis has led to the recognition of these processes as important determinants of bone disease. This is further supported by the recognition that the immune and bone systems in fact share regulatory mechanisms and progenitor molecules. Research into this complex synergy has provided a better understanding of the immunopathogenesis underlying bone diseases such as osteoporosis. However, existing research has largely focussed on delineating the role played by inflammation in pathogenic bone destruction, despite increasing evidence implicating autoantibodies as important drivers of osteoporosis. This review shall attempt to provide a comprehensive overview of existing research examining the role played by autoantibodies in osteoporosis in order to determine the potential for further research in this area. Autoantibodies represent promising targets for the improved treatment and diagnosis of inflammatory bone loss.

【 授权许可】

Unknown