The Differences of Effectivness HBO 2,4 ATA Between 7 and 10 Days In Bone Remodelling of Tension Area of Orthodontic Tooth Movement

12th Congress of Indonesian Soc. for Biochemistry and Molecular Biology in Conjunction With The 2nd Int. Conf. "Collaboration Seminar of Chemistry and Industry

生物科学;化学

Brahmanta, A.^1 ; Mulawarmanti, D.^2 ; Ramadhani, F.Z.^3 ; Widowati, W.^3

Orthodontic Departement, Faculty of Dentistry Hang, Tuah University, Surabaya, Indonesia^1

Biochemistry Department, Faculty of Dentistry Hang, Tuah University, Surabaya, Indonesia^2

Tuah University, Surabaya, Indonesia^3

关键词: Bone remodelling;    Hyperbaric oxygen therapies;    Inflammatory mediators;    Orthodontic Tooth;    Orthodontic tooth movements;    Osteocytes;    Periodontal ligament;    Tissue oxygenation;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/217/1/012059/pdf
DOI  :  10.1088/1755-1315/217/1/012059

学科分类：生物科学（综合）

来源: IOP

【 摘 要 】

Mechanical force of orthodontics, would inhibit periodontal ligament vascularization and blood flow, causing biochemical and cellular changes, such as cell deformation, inflammation, and circulatory disturbances. Each of these conditions afecting cell diferentiation, cell repair, and cell migration, is driven by numerous molecular and inflammatory mediators. Fibroblasts, osteoblasts, osteocytes, osteoclasts, odontoblasts, cementoblasts, chondrocytes and immune cells are the major cell types involved in the remodeling process on orthodontic tooth movement. Hyperbaric oxygen therapy is one of many solutions which stimulates the growth of new blood vessels and result in a substantial increase in tissue oxygenation. It plays a role in bone remodeling process.Purpose: To determine the differences of Hyperbaric Oxygen (HBO)2.4 ATA 7 and 10 days in osteoblast and osteocytes number during bone remodelling in Orthodontic tooth movement. Materials and Methods: The experiment using a post test only control group design. 32 male guinea pigs were randomly divided into 4 groups. K1 was control group without any treatment, K2 was a group which was given a mechanical orthodontic pressure, K3 was the group treated mechanical orthodontic with the addition of hyperbaric oxygen therapy. The maxillary incisors were moved distally by elastic separator. After HBO on day 7, all groups were sacrificed then analyzed osteoblast and osteocytes number by One-way ANOVA and LSD statistical test. Results: The study showed significant differences in osteoblast and osteocytes number during bone remodelling in orthodontic tooth movement between groups.Conclusion: HBO therapy 2.4 ATA for 7 days effective to induce bone remodelling during orthodontic tooth movement.