Scleroderma: a case report

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Harahap, T.A.^1 ; Marpaung, B.^1

Division of Rheumatology, Department of Internal Medicine, Faculty of AMedicine, University of Sumatera Utara, Indonesia^1

关键词: Autoantibodies;    Average ages;    Case reports;    Complex disease;    Fingers and toes;    Omeprazole;    Physical examinations;    Sclerosis lesions;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012159/pdf
DOI  :  10.1088/1755-1315/125/1/012159

来源: IOP

【 摘 要 】

Scleroderma is a complex disease in which extensive fibrosis, vascular alterations, and autoantibodies against various cellular antigens are among the principal features.[1,2] The prevalenceranging from 50 to 300 cases per 1 million persons with women are at much higher risk. The average age of diagnosis is the fifth decades of life.[2] There is no cure for scleroderma, but many of its problems and complications can be treated.[3-7]A 54-year-old female patient with main complains limitation of motion and mouth, stiffness and painful joints in the hands and feet, thickening on the skin in the chest and trunk for eight years, purplish red spots on arms and legs intermittent for tenyears. On physical examination found sclerosis lesions, sclerodactyly on fingers and toes, telangiectasias in the antebrachii and cruris region. On laboratory, examination showed ANA test 10.7 and Anti DS DNA 123. The histopathological of the skin result is scleroderma. The patient was diagnosed with scleroderma and treated with methotrexate 7.5 mg/weeks, ciclosporin 2×100 mg/day, omeprazole 2×20 mg. After seven days of therapy, there is aclinical improvement, and the patient becomes anoutpatient treatment.