Comparative measurements of bone mineral density and bone contrast values in canine femora using dual-energy X-ray absorptiometry and conventional digital radiography

BMC Veterinary Research

Methodology Article

C. Stukenborg-Colsman¹  M. Lerch¹  A. Almohallami²  S. Betancur²  B. A. Behrens²  A. Bouguecha²  V. Galindo-Zamora³  P. Wefstaedt⁴  I. Nolte⁴  K. Lucas⁴ 

[1] Department of Orthopaedic Surgery, Hannover Medical School, Hanover, Germany;Institute of Forming Technology and Machines, Leibniz University Hannover, Hannover, Germany;Small Animal Clinic, Faculty of Veterinary Medicine, National University of Colombia, Bogotá, Colombia;Small Animal Hospital, University of Veterinary Medicine Hannover, Foundation, Bünteweg 9, D-30559, Hannover, Germany;

关键词: Bone mineral density;    DEXA;    Digital radiography;    Canine;    Femur;    Bone remodelling;   

DOI  :  10.1186/s12917-017-1047-y

 received in 2015-11-24, accepted in 2017-05-04,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for quantitative evaluation of bone mineral density, whereas in veterinary medicine conventional radiography is used for follow-up studies. Recently, a method has been described using digital X-ray images for quantitative assessment of grey scale values of bone contrast. Therefore, the aim of the present study was to evaluate the correlation of bone mineral density (BMD) measured by DEXA with grey scale values (GV) measured in digital X-ray images (RX50, RX66) ex vivo.ResultsThe measured GV in the chosen X-ray settings showed on average a good correlation (r = 0.61) to the measured BMD with DEXA. Correlation between the two X-ray settings was very good (r = 0.81). For comparisons among regions of interests (ROIs) a difference of 8.2% was found to be statistically significant, whereas in the case of RX50 and RX66 differences of 5.3% and 4.1% were found to be statistically significant.ConclusionsResults indicate that measuring absolute changes in bone mineral density might be possible using digital radiography. Not all significant differences between ROIs detectable with DEXA can be displayed in the X-ray images because of the lower sensitivity of the radiographs. However, direct comparison of grey scale values of the periprosthetic femur in one individual patient during the follow-up period, in order to predict bone remodelling processes, should be possible, but with a lesser sensitivity than with DEXA. It is important that the same X-ray settings are chosen for each patient for follow-up studies.

【 授权许可】

CC BY   
© The Author(s). 2017