期刊论文详细信息
Marine Drugs
Antibacterial and Antibiofilm Activities of Tryptoquivalines and Meroditerpenes Isolated from the Marine-Derived Fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the Soil Fungi N. fischeri and N. siamensis
Artur M. S. Silva1  Tida Dethoup2  Jamrearn Buaruang3  Anake Kijjoa4  Lucinda J. Bessa4  Nelson M. Gomes4  Paulo M. Costa4  Suradet Buttachon4 
[1] Departamento de Química, Universidade de Aveiro, Aveiro 4810-1933, Portugal;Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok 10240, Thailand;Division of Environmental Science, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand;ICBAS—Instituto de Ciências Biomédicas de Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, Porto 4050-313, Portugal;
关键词: antibacterial;    antibiofilm;    multidrug-resistant;    tryptoquivalines;    meroditerpenes;    Neosartorya;    marine-derived fungi;   
DOI  :  10.3390/md12020822
来源: DOAJ
【 摘 要 】

A new meroditerpene, sartorypyrone C (5), was isolated, together with the known tryptoquivalines L (1a), H (1b), F (1c), 3′-(4-oxoquinazolin-3-yl) spiro [1H-indole-3,5′]-2,2′-dione (2) and 4(3H)-quinazolinone (3), from the culture of the marine sponge-associated fungus Neosartorya paulistensis (KUFC 7897), while reexamination of the fractions remaining from a previous study of the culture of the diseased coral-derived fungus N. laciniosa (KUFC 7896) led to isolation of a new tryptoquivaline derivative tryptoquivaline T (1d). Compounds 1a–d, 2, 3, and 5, together with aszonapyrones A (4a) and B (4b), chevalones B (6) and C (7a), sartorypyrones B (7b) and A (8), were tested for their antibacterial activity against four reference strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa), as well as the environmental multidrug-resistant isolates. Only aszonapyrone A (4a) and sartorypyrone A (8) exhibited significant antibacterial activity as well as synergism with antibiotics against theGram-positive multidrug-resistant strains. Antibiofilm assays of aszonapyrone A (4a) and sartorypyrone A (8) showed that practically no biofilm was formed in the presence of their 2× MIC and MIC. However, the presence of a sub-inhibitory concentration of ½ MIC of 4a and 8 was found to increase the biofilm production in both reference strain and the multidrug-resistant isolates of S. aureus.

【 授权许可】

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