Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Molecules

Bing-You Yang¹  Yan Liu¹  Zun-Peng Shu¹  Hai Jiang¹  Rui Guo¹  Ting Li¹  Chang-Fu Wang¹  Jing Zhang¹  Qiu-Hong Wang¹  Zhi-Bin Wang¹  Yong-Gang Xia¹  Hai-Xue Kuang¹ 

[1] Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China;

关键词: Datura metel L.;    withanolides;    dmetelins;    NO inhibition;   

DOI  :  10.3390/molecules19044548

来源: DOAJ

【 摘 要 】

Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively.

【 授权许可】

Unknown