The Constituents of Michelia compressa var. formosana and Their Bioactivities

International Journal of Molecular Sciences

Yu-Yi Chan¹  Shin-Hun Juang²  Guan-Jhong Huang⁶  Yu-Ren Liao⁴  Yu-Fon Chen³  Chia-Che Wu⁵  Hui-Ting Chang⁵ 

[1] Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan;Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan; E-Mail:;Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan; E-Mail:;Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan; E-Mail:;School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan; E-Mails:;Department of Pharmacy, China Medical University, Taichung 40402, Taiwan; E-Mail:

关键词: Michelia formosana;    Magnoliaceae;    NO inhibition;    macrophage;    cytotoxicity;   

DOI  :  10.3390/ijms150610926

来源: mdpi

【 摘 要 】

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC₅₀ values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC₅₀ values in the range of 15.7–3.68 μM.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.