Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

Molecules

Tran Dinh Thang⁴  Ping-Chung Kuo²  Guan-Jhong Huang⁵  Nguyen Huy Hung⁴  Bow-Shin Huang²  Mei-Lin Yang¹  Ngo Xuan Luong³ 

[1] Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan;Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan; E-Mail:;Department of Natural Science, Hong Duc University, Thanhhoa 41000, Vietnam;Department of Chemistry, Vinh University, Vinh 42000, Vietnam; E-Mail:;Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan

关键词: Annona;    triterpenoid;    diterpenoid;    NO inhibition;    iNOS;    macrophage;   

DOI  :  10.3390/molecules18044477

来源: mdpi

【 摘 要 】

In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC₅₀ values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.

【 授权许可】

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.