Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

Molecules

关键词: Annona;    triterpenoid;    diterpenoid;    NO inhibition;    iNOS;    macrophage;   

DOI  :  10.3390/molecules18044477

来源: DOAJ

【 摘 要 】

In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.

【 授权许可】

Unknown